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Volume 359:2727-2728 December 18, 2008 Number 25
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Platelets and the Vascular Wall

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by Nachman, R. L.
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To the Editor: In their review of the importance of platelets in maintaining the integrity of the vascular wall, Nachman and Rafii (Sept. 18 issue)1 provide evidence that maintenance of the endothelial barrier depends on a reciprocal communication between endothelial cells and platelets and the formation of zipper structures at adherens junctions. A protein that is central in the activation status of platelets and endothelial zipper structures is vasodilator-stimulated phosphoprotein (VASP). VASP is crucial for the polymerization of the actin cytoskeleton and is intimately linked to several proteins forming adherens junctions, such as {alpha}-catenin. Endothelial cells deficient in VASP are . . . [Full Text of this Article]



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