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Volume 358:850-853 February 21, 2008 Number 8
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Computed Tomography and Radiation Exposure

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 by Brenner, D. J.
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To the Editor: Computed tomographic (CT) scans deliver a radiation dose of about 20 mSv. Brenner and Hall (Nov. 29 issue)1 assess the risk associated with CT radiation exposure by using the linear no-threshold extrapolation model, which assumes that cancer induction is proportional to dose even for the smallest doses. An excess of cancers has never been detected in laboratory animals or in humans for doses below 100 mSv. This model is used for analyzing data from cohorts including persons who have received doses higher than 100 mSv. This method is exposed to strong bias.2 Defense mechanisms against radiocarcinogenesis are . . . [Full Text of this Article]


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