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Editorial
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Volume 359:2488-2491 December 4, 2008 Number 23
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Chronic Hepatitis B — New Goals, New Treatment
Ching-Lung Lai, M.D., and Man-Fung Yuen, M.D.

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by Marcellin, P.
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The hepatitis B virus (HBV) causes chronic infection in approximately 400 million people in the world. Most carriers of chronic HBV, including Asians, Africans, and a proportion of persons in Mediterranean countries, acquire the infection at birth or within the first 1 to 2 years after birth.1 It is estimated that 50% of male carriers and 14% of female carriers will eventually die of the complications of cirrhosis and hepatocellular carcinoma.2

The criteria and end points for the treatment of chronic HBV infection should be reevaluated in light of three important recent findings. First, more than 70% of patients with . . . [Full Text of this Article]


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From the Department of Medicine, University of Hong Kong, Hong Kong.



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