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Volume 359:2066-2068 November 6, 2008 Number 19
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Cellulose Sulfate for Prevention of HIV Infection

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by Van Damme, L.
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To the Editor: The results of the trial of cellulose sulfate as a vaginal gel for the prevention of human immunodeficiency virus (HIV) infection, reported by Van Damme et al. (July 31 issue),1 indicated that cellulose sulfate did not prevent sexual transmission of HIV and may have increased the risk of HIV acquisition, as compared with placebo. The cellulose sulfate and placebo gels had a pH of 7.5 and 4.4, respectively. The healthy human vagina provides a low pH, diminishing HIV infectivity and transmission of cell-associated HIV.2,3 Therefore, microbicides should have a pH of approximately 4.5.3 The apparently increased risk . . . [Full Text of this Article]



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